AS-IV inhibits AMPK signaling pathway, Akt/GSK-3β/β-Catenin, endoplasmic reticulum stress signaling pathway, and autophagy signaling pathway and evidence in previous studies also proved AS-IV inhibits the proliferation of NSCLC and promotes apoptosis [21,22,37]. The gene discussed is AKT1; the disease is non-small cell lung carcinoma.