In addition, glycolysis-related enzymes were increased in PAH lungs, including glycolytic regulator PFKFB2 (6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase) (Zhao et al., 2014) and PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3). This evidence concerns the gene PFKFB3 and pulmonary arterial hypertension.