Their components mainly include HSP27, HSP40, HSP60, HSP70, HSP90, etc.12It has been reported that these proteins are highly expressed in a series of cancers, such as breast, prostate, colorectal, lung, ovarian, gastric, oral and oesophageal cancers, and their expression contributes to cancer proliferation, invasion and metastasis.13 The gene discussed is DNAJB1; the disease is carcinoma of esophagus.