Future cohort studies are warranted to determine the proportion of children born with normal hearts even when both parents are heterozygous for PLD1. We hope that this report will help to elucidate the causes of repeated CHD, particularly for genetic counseling for right ventricular valve dysplasia, and that the accumulation of such information will lead to more detailed information on PLD1 mutations in heart disease. This evidence concerns the gene PLD1 and coronary artery disorder.