ROC analyses showed that plasma exosomal MUC5B and SELL could differentiate LC patients with BM from HC and LC patients with LM and LA with an AUC value of 0.751 (95% CI 0.655–0.847, p < 0.001) and 0.728 (95% CI 0.641–0.815, p < 0.001), respectively (Fig. 11D). Here, MUC5B is linked to laryngotracheoesophageal cleft.