However, the striking impairment in proliferation, increased ROS content, and lipid peroxidation observed in vitro under basal conditions in tumor cells derived from BALB-neuT/xCTnull mice, and the finding that the addition of β-ME or re-expression of Slc7a11 is sufficient for the reversion of these phenotypes reveals indeed essential functions of xCT in the biology of these epithelial tumor cells under specific conditions. Here, SLC7A11 is linked to neoplasm.