Of the many Peptide5-sensitive changes observed, we identified several inflammatory proteins seen in CKD, the action of which are integral to the onset and progression of disease, e.g., granulocyte macrophage colony-stimulating factor (GM-CSF), epithelial neutrophil-activating peptide 78 (ENA-78), interleukin 24 (IL-24), resistin and leukemia inhibitory factor (LIF). This evidence concerns the gene CSF2 and chronic kidney disease.