Although SQLE has been shown as an oncogene that is overexpressed in several cancers, including hepatocellular carcinoma [16] (HCC) and colorectal cancer [17] (COAD), and overexpression of SQLE tends to bring a bad prognosis in these cancers, the interaction between BCa and SQLE remains poorly understood. The gene discussed is SQLE; the disease is hepatocellular carcinoma.