AKT1 and neoplasm: Studies have confirmed that lipid accumulation is primarily regulated by SREBF family transcription factors [7], which aberrantly activate a bunch of signal pathways, such as the phosphatidylinositol-3 kinase (PI3K)/AKT signaling pathway [8–10] and the MAP kinase (MAPK) signaling pathway [11], which play a vital role in promoting tumor cell growth, migration, and invasion.