According to available clinical data, most infected patients develop varying degrees orchitis and genital tract inflammation, additionally, the overproduction of cytokines that regulate the immune response (IL-6, etc.)induced by a viral infection can lead to leukocyte infiltration in the interstitium of testis, resulting in autoimmune response and formation of anti-sperm antibodies (ASA) [25] and autoimmune responses appear to play an important role in the negative effects of COVID-19 on fertility. The gene discussed is IL6; the disease is orchitis.