In their prospective longitudinal cohort study, the levels of inflammatory markers (IL-1β, IL-6, IL-8, IL-10, TGF-β, INF-α, and INF-γ) in the semen of the COVID-19 positive group were significantly higher than those of the control group from the first sampling to up to 60 days of follow-up thereafter (p < 0.05). This evidence concerns the gene IL10 and COVID-19.