Our previous study identifies that TFE3 rRCC exerts a preference for oxidative phosphorylation, which is different from common RCCs [16, 17], and nicotinamide ribokinase 2 (NMRK2) upregulated by TFE3 fusion is associated with enhanced mitochondrial respiration and tumor progression in TFE3 rRCC [16]. Here, TFE3 is linked to neoplasm.