Proteins like Profilin 1 (PFN1), H4 Clustered Histone 1 (H4C1), Annexin A1 (ANXA1), S100 calcium-binding protein A11 (S100A11) and Lactate Dehydrogenase (LDH1) were found to be upregulated in high grade Meningioma in comparison to low grade. This evidence concerns the gene PFN1 and meningioma.