Current noninvasive predictions of liver fibrosis mainly include LSM and biomarkers like Chitinase 3-like 1 (CHI3L1) [25, 26], Golgi protein 73 [27], et al. The detection of the newly-developed noninvasive markers has not yet been applied widely and their diagnostic accuracies are still limited. The gene discussed is CHI3L1; the disease is Hepatic fibrosis.