ATAD2 and cancer: While ATAD2 was initially identified as a transcriptional co-activator of estrogen and androgen receptors9,10, cMYC3, and E2F11 in human cancer cells, studies of yeast ATAD2 homologs suggest that ATAD2 is multifaceted, serving not only as a transcriptional regulator but also as a histone chaperone and chromatin boundary element12.