PFKFB4 and prostate cancer: Moreover, PFKFB4 by reducing prostate cancer cells fructose-2,6-bisphosphate level, make the glucose-6-phosphate guide the PPP, reduces the glycolytic pathway activity, make the NADPH and glutathione levels, eventually reduce the oxidative stress and death of tumor cells, prevent prostate cancer cells apoptosis, promote the growth of tumor20.