Expression of CXCL8 chemokine which has angiogenic and pro-inflammatory activity is also known to affect tumor cells, inducing the proliferation of LC cells through CXCR162.The CXCL8 (secreted by tumor cells)-CXCR1/2 (in TME) axis may also regulate CSC proliferation and self-renewal thus play a critical role in LC progression and metastasis in TME63. Here, CXCR1 is linked to laryngotracheoesophageal cleft.