The first highest order miR-200 family-associated subnetwork motif comprised miR-200a-3p, CX3CR1 and SPIB. miR-200 family has been reported to function as an oncogene or tumor-suppressor in several carcinogenesis, but its crucial biological importance and functions in NSCLC are subtle. This evidence concerns the gene SPIB and non-small cell lung carcinoma.