In line with previous studies9, administration of a single dose of anti-GPIbα antibody to Vwf-GFP mice, to mimic the thrombocytopenia observed in patients with immune thrombocytopenia purpura (ITP), rapidly and efficiently depleted platelets in the course of 1 day without significantly affecting other blood cell lineages (Fig. 1a). Here, VWF is linked to Thrombocytopenia.