Therefore, to investigate if IL-1 may directly mediate the activation of HSCs post anti-GPIbα-induced thrombocytopenia we induced platelet depletion in Il1r1FL/FLVav-iCreTg/+ mice which targets deletion of Il1r1 to all hematopoietic cells, including HSCs. Here, IL1R1 is linked to Thrombocytopenia.