To broadly characterize how genetic driver aberrations influence imaging phenotypes, we constructed a screening mixed effects model (MEM) with the mutation status and copy number of top genetic drivers of GBM (EGFR, NF1, TP53, PTEN, and CDKN2A) modeled as fixed effects with no interacting terms and patient effects specified as random effects. Here, EGFR is linked to glioblastoma.