A more frequent MLKL loss-of-function gene variant (p.Gln48Ter, rs763812068) was found to be >20 fold enriched in a cohort of Hong Kong Chinese patients suffering from Alzheimer’s disease37 and common variants that cluster around the MLKL brace region were shown to be enriched in trans in a cohort of Chronic Recurrent Multifocal Osteomyelitis patients33. Here, MLKL is linked to chronic recurrent multifocal osteomyelitis.