We found that several DAMP-related genes, including Hmgb1, Calr, and Anxa1, were significantly overexpressed in Ero1aKO tumor cells compared with WT controls, suggesting the intracellular danger signaling pathways that govern ICD in Ero1aKO tumors (Figures 3F and 3G). The gene discussed is CALR; the disease is neoplasm.