Moreover, the subcellular location and function of NSUN2 in cell proliferation and migration were verified, suggesting that NSUN2 is mainly located in the nucleus and that highly expressed-NSUN2 can serve as an oncogene as well as a prognostic biomarker across cancers, suggesting that targeting NSUN2 might be a potential therapeutic strategy for tumor immunotherapy. This evidence concerns the gene NSUN2 and cancer.