Last, a similar link between primary ciliary defects and EMT in the RPE was also made in a murine model of the syndromic retinal ciliopathy Bardet-Biedl syndrome (BBS8–/–), where an EMT-like phenotype was associated with defective cellular polarization and morphology (21), further validating our observations. This evidence concerns the gene TTC8 and Bardet-Biedl syndrome.