In addition, AMH appears to be one of the key factors in PCOS pathogenesis through the reprogramming of the fetus and possibly predisposes one to exhibit PCOS traits in adulthood, as pregnant mice administered a high dose of AMH experienced persistent hyperactive GnRH pulsatility that was passed on to female progeny [102, 103]. The gene discussed is GNRH1; the disease is polycystic ovary syndrome.