Recently, Jakubiak et al. (2021) discovered that obesity and insulin resistance had the strongest relationship with oxidative stress among metabolic syndrome components such as “obesity and insulin resistance,” “dyslipidemia,” and “blood pressure.” It is worth noting that NRF2 and PER3 are related to the redox cycle and adipogenesis. This evidence concerns the gene PER3 and obesity due to melanocortin 4 receptor deficiency.