CRY1 and mood disorder: It has been reported that certain polymorphic variants of SIRT1, as well as other circadian genes such as Circadian Locomotor Output Cycles Kaput (CLOCK), Brain and Muscle Arnt-Like 1 (BMAL1, also known as aryl hydrocarbon receptor nuclear translocator-like 1, ARNTL1), Cryptochrome 1 (CRY1) may lead to insulin resistance and increase the risk of metabolic and mood disorders (Dong et al. 2011; Dashti et al. 2014; Kovanen et al. 2015; Angelousi et al. 2018).