NFE2L2 and Cognitive impairment: They have been reported in the studies on acute respiratory distress syndrome and adult-onset cognitive deficits induced by Phencyclidine as possible functional variants in the NFE2L2 gene (Acosta-Herrera et al. 2015; Shirai et al. 2015) NFE2L2 (Nuclear factor-erythroid 2 like, also known as NRF2) is a transcription factor that regulates redox metabolism in cells.