For a better understanding of the role of NfL, GFAP and tau on ICU admission in critical COVID-19, a correlation network was created, revealing that NfL correlates primarily with age, renal function, CCI, CFS, altered consciousness before ICU admission, serum procalcitonin (PCT), and indirectly with interleukin-6 (IL-6) and albumin, apart from being correlated with GFAP and tau. This evidence concerns the gene NEFL and myalgic encephalomeyelitis/chronic fatigue syndrome.