CRP and metabolic dysfunction-associated steatotic liver disease: Another study indicated that liver fat played a crucial role in the regulation of protein C and protein S. It also demonstrated that NAFLD patients had elevated levels of C-reactive protein (CRP), fibrinogen, plasminogen activator inhibitor-1 (PAI-1), von Willebrand factors, and coagulation factor VII, which are known to be associated with an increased risk of thrombosis [96].