EGFR and non-small cell lung carcinoma: The optimal sequencing strategy appeared to be the combination of afatinib in the first line, followed by second-line osimertinib in a case of a proven T790M mutation (Hirsh et al. 2020; Kim et al. 2023), until the results of the FLAURA study have been published, shifting osimertinib to the first-line therapy of EGFR positive NSCLC (Lorenzi et al. 2022).