The salutary effects of adiponectin on glucose homeostasis, insulin sensitivity, and chronic low-grade inflammation, and the inverse association between the incidence of T2DM and cHMW adiponectin levels are known (Kadowaki et al., 2006; Lindsay et al., 2002; Spranger et al., 2003). This evidence concerns the gene ADIPOQ and type 2 diabetes mellitus.