Previous studies in the mouse model studies have shown that cHMW adiponectin enhances insulin sensitivity and plasma lipid clearance; high levels of cHMW adiponectin improve the stability of lipid homeostasis and provided systemic tolerance to obesity under normal physiological conditions (Combs et al., 2004; Qiao et al., 2008; Asterholm and Scherer, 2010). This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.