Gastric cancer tissues showed more positive staining with GPX4 (Figure 2A and  2B), NRF2 (Figure 2C and  2D), and SLC7A11 (Figure 2E and  2F) when compared with adjacent non-tumor tissues; GPX4 and NRF2 staining was mainly seen in the nucleoplasm or cytoplasm, while SLC7A11 staining patterns were mainly cytoplasmic. The gene discussed is NFE2L2; the disease is neoplasm.