Previously, researchers noticed that the proliferation and malignant behaviors could be inhibited by inducing ferroptosis in HGC-27 and AGS cells.26 In fact, compared with paracancerous tissues, ferroptosis was significantly inhibited in GC cells, which is considered to promote tumor growth and reduce the sensitivity of cisplatin and paclitaxel chemotherapy.27 Current studies revealed some possible mechanisms of ferroptosis escape in GC, which involve the abnormal expression of cysteine dioxygenase 1,28 perilipin 2,29 stearoyl-CoA desaturase 1,30 and other factors. The gene discussed is PLIN2; the disease is gastric cancer.