It has been reported that SLC7A11 is highly expressed in some cancers, for example, lung cancer21 and colon cancer.22 A recent work had demonstrated that CD44-induced chemoresistance in GC could be attenuated by the inhibition of SLC7A11.23 In addition, Chinese herbal medicines such as Actinidia chinensis Planch24 and Tanshinone25 can inhibit the expression of SLC7A11 in GC cells, which finally aggravated ferroptosis and exerted antitumor effects. This evidence concerns the gene CD44 and gastric cancer.