Scanned digital images were quantitatively analyzed and 14 immune subsets were quantified, including total CD4 and CD8 T cell and their subsets (FOXP3+ Tregs, BCL6+ T follicular helper T cells (Tfh) HLA-DR+ activated T cells, and TCF1+ T cells), B cells, γδ T cells, M1/M2 tumor-associated macrophages (TAM), tumor-associated neutrophils (TAN), and APCs (Lin-HLA-DR+; Fig. 1C; Supplementary Fig. S1A). Here, CD4 is linked to neoplasm.