The relationship between HP infection and GC has been the subject of numerous studies, but these studies primarily concentrate on the oncogenic effects of HP strains’ virulence factors, such as BabA, CagA, oipA, and VacA, as well as environmental risk factors like increased or decreased gastric fluid pH and nitrosamines and their precursors [41–44]. The gene discussed is S100A8; the disease is gastric cancer.