K-M curves uncovered that only eight hub genes (EFNA3, FLT1, L3MBTL3, MAPK10, MLEC, MYB, NRP1, as well as UHRF1) existed a significant difference in the clinical outcomes of GC patients between high and low-expression subgroups (Figure 5A–5H). This evidence concerns the gene EFNA3 and gastric cancer.