The above results show that myeloid-specific knockout SHP2 mediates the PI3K/PLCγ signaling pathway, affects the expression of inflammatory factors and the level of phagocytic activity, thereby promoting the phagocytic activity of macrophages and reducing the content of inflammatory factors, thereby protecting early myocardial infarction injury (Figure 8). Here, PTPN11 is linked to myocardial infarction.