REEP5 and infection: To understand the role of REEP5 in ER morphology and SARS-CoV-2-induced DMVs, we infected parental and REEP5 KO Calu-3 cells with SARS-CoV-2 and compared their morphology at 0 (Fig. 7A and B) and 24 hours (Fig. 7C and D) after infection using electron microscopy.