Together with the 3 documents talked above, the Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy (17), Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota (16), and Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients (20) are the six top local cited reference. Here, CD274 is linked to melanoma.