These documents were probably the cornerstones of the field, intended for figuring out the clear relationship the detailed mechanisms how gut microbiota affected the differentiation and function of immune cells in the tumor microenvironment and how gut microbiota change tumor immunosurveillance and the therapeutic efficacy of PD-1 and CTLA-4 blockades as well as chemotherapy. This evidence concerns the gene CTLA4 and neoplasm.