LYZ and colitis: To confirm the role of PPARγ in DSS-induced colitis, we utilized PPARγ conditional knockout (PPARγcKO) mice originally derived by crossing homozygous floxed PPARγ mice with a transgenic mouse containing the Cre recombinase gene under the control of the murine Lysozyme M (Lyz2) promoter to delete the Pparg gene in lysozyme-producing cells (i.e., predominantly Mφ and neutrophils) (133, 147, –, 149).