RNA-seq data from SUM159 cells revealed that hypoxia-induced the expression of NARF mRNA,13 which encodes nuclear prelamin A recognition factor, a poorly characterized nuclear protein that is also known as iron-only hydrogenase-like protein 2 (despite its name, it has no hydrogenase activity).60,61 NARF has not been previously implicated in breast cancer pathogenesis or cancer stem cell biology. The gene discussed is NARF; the disease is breast cancer.