PLXNB3 mRNA expression was induced by hypoxia in SUM159 human TNBC cells as part of a battery of RNAs associated with axon guidance13 and was correlated with the expression of a HIF metagene signature in 1218 human breast cancers in The Cancer Genome Atlas (TCGA BRCA dataset).54 Immunohistochemical analysis revealed that HIF-1α and PLXNB3 protein expression were highly correlated in human breast cancers and that PLXNB3 protein expression greater than the median was associated with decreased overall survival of women with breast cancer.54 This evidence concerns the gene HIF1A and breast carcinoma.