NANOG and breast carcinoma: In addition, NANOG interacted with the histone acetyltransferase p300 to stabilize its interaction with HIF-1α, thereby increasing acetylation of histone H3 at lysine residue 9 (H3K9ac) and H3K27ac, which are histone marks associated with transcriptional activation, at the TERT promoter.72 Thus, NANOG functions as a coactivator that increases HIF-1α protein stability and transactivation function in breast cancer cells.