CTLA4 and Autoimmunity: From a molecular point of view, LRBA prevents AP-1 driven CTLA-4 lysosomal degradation by recycling and cell surface transferring CTLA-4-containing vesicles; therefore, patients lacking wild-type LRBA expression display decreased CTLA-4 expression and altered T-reg function, thus causing immune dysregulation and autoimmunity [38].