LASSO regression identified BMI, MAMC, albumin, irisin, creatinine, haematocrit, myostatin, C‐reactive protein (CRP), FGF‐21, sCD14, DAO, bilirubin, ALT, activated partial thromboplastin time (APTT), CA:CDCA, GDCA:CA, TDCA:CA, GLCA:CDCA, GDCA:DCA, TDCA:DCA, GLCA:LCA, TLCA:LCA, T‐UDCA:total‐sec‐BAs, 12‐α‐OH:non‐12‐α‐OH BAs, valine, phenylalanine, alanine and acetate to be associated with sarcopenia in cirrhosis. The gene discussed is FGF21; the disease is Cirrhosis.