This leads to disarrangement of the cyto-skeleton and loss of spatial orientation of F-actin fibers, possibly impairing receptor recycling and degradation.54 Importantly, the Arp2/3 complex is a crucial regulator of lamellipodia and filopodia protrusion formation by initiating branched F-actin polymerization,55 which has not been studied in the context of preeclampsia. Here, ACTR2 is linked to preeclampsia.