Regulators of F-actin polymerization include the complex of ARP2/3 (actin-related proteins 2 and 3), cofilin (active form), and phosphorylated cofilin (inactive form), which are critical regulators of the disassembly of F-actin filaments.25 To date, no information regarding impairment of F-actin polymerization and brain endothelial cell migration has been described in preeclampsia. Here, ACTR2 is linked to preeclampsia.