In particular, copper stabilizes nuclear HIF1α even under normoxic conditions, which in turn promotes the expression of vascular endothelial growth factor (VEGF) by cooperating with the G-protein estrogen receptor (GPER), leading to angiogenesis in breast and liver cancers (Martin et al., 2005; Rigiracciolo et al., 2015). This evidence concerns the gene VEGFA and liver cancer.