ATP7A and breast carcinoma: The best example is D-penicillamine, which can inhibit tumor growth in oxaliplatin-resistant human cervical cancer cells by interfering with the Sp1-hCtr1-p53-ATP7A axis and enhancing the lethality of radiation and carboplatin against lung and breast cancer cells (Chen et al., 2015; Sciegienka et al., 2017).