In clear cell renal cell carcinoma (ccRCC), high expression of FDX1 and DLAT predicts better survival; however, CDKN2A exhibits carcinogenic features, the overexpression of which is associated with worse survival in patients with ccRCC (Bian et al., 2022). The gene discussed is CDKN2A; the disease is nonpapillary renal cell carcinoma.