KDR and hepatocellular carcinoma: Sorafenib is the first-line FDA-approved treatment for HCC (Niu et al., 2021) and an oral multikinase inhibitor that targets vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor (PDGFR), hepatocyte factor receptor (KIT), or other molecules to decrease angiogenesis.