KCNH2 and cancer: In particular, in cancer cells hERG1 regulates slowly changing resting potential values (Vrest), clamping them at rather depolarized values compared to normal cells (Schonherr et al., 1999), and triggers intracellular signaling pathways involved in cell survival, proliferation, motility and invasion, often exerting non-conductive roles (Becchetti et al., 2022).