APOE and hyperinsulinemic hypoglycemia, familial, 4: Similarly, acacetin not only significantly relieved oxidized-LDL-induced ROS accumulation and apoptosis in human endothelial cells via the MsrA-Keap1/Nrf2 pathway but also halted atherogenesis in apolipoprotein E deficiency (apoE−/−) mice via accelerating lipid metabolism and decreasing plasma inflammatory cytokines (Wu et al., 2021).