NFE2L2 and colorectal adenocarcinoma: Zuo et al. found that luteolin blocked cell growth and colony formation of human colorectal adenocarcinoma HCT116 cells via activating Nrf2, Ho-1, and NQO1; Paredes-Gonzalez et al. found apigenin exhibited cytotoxicity and restored the expression of Nrf2 in the preneoplastic epidermal JB6 P + cell line.