Several reports have documented dwarfism resulting from defective Igf1 secretion due to Ghr dysfunction (Rosenbloom and Guevara-Aguirre, 1998; Werner et al., 2020).Ghrknockout experiments in mice and pigs have successfully replicated the LS phenotype (Zhou et al., 1997; Cui et al., 2015), emphasizing the crucial role of Ghr in determining mammalian body size. The gene discussed is GHR; the disease is Severe short stature.