Here, we used the FUS[1–359]-tg mouse line, expressing a truncated highly-aggregate-prone form of human FUS, which displays FTLD-like and ALS-like disease halmarks in both pre-symptomatic and symptomatic stages at 8 and 14 weeks respectively (de Munter et al., 2020a, 2020b; Probert et al., 2022; Sambon et al., 2020; Shelkovnikova et al., 2013), in conjunction with a systemic lipopolysaccharide (LPS) challenge. This evidence concerns the gene FUS and amyotrophic lateral sclerosis.