Animal and in vitro research has revealed that hyperactivity within the MTL enhances both amyloid and tau pathology in the HP and ERC,51,56–58,125,126 while the earliest stages of neuronal dysfunction in Alzheimer’s disease mice are characterized by Aβ-induced hyperactivity with hypoactivation appearing in later stages of the disease.127 Using mice models of Alzheimer’s disease, Angulo et al.52 studied the effects of Aβ and tau on ERC neurons specifically. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.