Compared with Cluster1, Cluster2, with poorer prognosis, had chromosomal amplification of various tumor-promoting gene loci, such as E2F3, MYC, and GATA3, and partial or complete deletion of the chromosome where the tumor suppressor gene PTEN and RB1 loci are located (Supplementary Figure 3). The gene discussed is RB1; the disease is neoplasm.