Therapy of 50% v/v forest honey for ten consecutive days in female rats with ovarian failure reveals the following findings: increased antioxidant enzyme activity, such as SOD, and decreased oxidative stress concentration, such as MDA; increased anti-inflammatory cytokine expression, such as IL-13, and decreased pro-inflammatory cytokine expression, such as TNF-α; and ovarian tissue regeneration with increased growing follicle count. Here, TNF is linked to ovarian dysfunction.