FN1 and cancer: Conventional 2D cancer cell culture systems have limitations in that even though 2D plates are coated with an extracellular matrix (ECM), such as collagen, laminin, and fibronectin, they cannot mimic the physiological patterns, such as cell–cell interactions, hypoxia, drug penetration, and resistance, noted in the tumor tissues of patient with cancer [[6], [7], [8]].