To broaden our investigation, we conducted a comprehensive evaluation comparing the in vivo efficacy of VNLG-152R’s deuterated analogs, namely D6, D7 and H6, with the parent compound in three different tumor xenografts of MDA-MB-231 (derived from Caucasian female metastatic mammary adenocarcinoma, low AR/AR‐), MDA-MB-468 (derived from metastatic mammary adenocarcinoma of an African female patient and AR‐), and MDA-MB-453 of Caucasian female origin with high AR expression. Here, AR is linked to neoplasm.