Besides delineating the molecular mechanism of action of VNLG-152-induced degradation of MNK1 and MNK2, we clearly demonstrate that VNLG-152R and its deuterated analogs effectively inhibit TNBC tumor xenografts of both Caucasian and African origins, including those with low or no AR expression as well as the Caucasian race with high AR expression. The gene discussed is MKNK1; the disease is neoplasm.