Another significant finding of this study is that VNLG-152R caused dose-dependent depletion of WNK1 (Figure 3D) which is implicated in cell migration, invasion, and metastasis in multiple cancer types including glioblastoma (83), prostate cancer (84), non-small cell lung cancer (85), and breast cancer (45, 46, 86, 87). Here, WNK1 is linked to glioblastoma.