MKNK1 and breast carcinoma: Notably, transcriptome and proteome analyses using data from The Cancer Genome Atlas (TCGA) and Clinical Proteomic Tumor Analysis Consortium (CPTAC) have revealed consistent upregulation of MNK1/2 and eIF4E in most breast cancer cases at mRNA and protein level except MNK1 mRNA (Figures 2A–F).