Since MNK1/2 are at the crossroads of other signaling pathways vital for the cancer development and progression such as mTORC1-4E-BP1 signaling and eIF4E signaling axes (16, 72), restraining MNK1/2 significantly inhibits cancer cells proliferation, cell migration, invasion, and metastasis (71). Here, EIF4EBP1 is linked to cancer.