In 99mTc-PSMA SPECT/CT combined with mpMRI, when the cut-off value for SUVmax/ADCmin was set at 7.0×103, the sensitivity and specificity of SUVmax/ADCmin in PCa were 93.2% (95%CI.85.7%-100.0%) and 100.0% (95%CI.100.0%-100.0%), respectively, with a Youden index of 0.932 and an AUC of 0.982 (95% CI. This evidence concerns the gene FOLH1 and posterior cortical atrophy.