Our previous study showed that 99mTc-labelled PSMA molecular probe (99mTc-HYNIC-Glu-Urea-A, herein referred to as 99mTc-PSMA) single-photon emission computed tomography (SPECT)/CT can display bone metastases of PCa with high sensitivity and specificity (9), with only a small amount of radiation uptake in the intestinal tract and no significant radiation uptake in other major organs (10). This evidence concerns the gene FOLH1 and posterior cortical atrophy.